Publications

Technostics is involved in many cutting-edge pre-clinical research areas in support of our product pipeline and maintains a high profile in the published literature. Some of our recent publications (2003 to January 2008) in these fields are listed below.

The abstracts for these publications can be accessed by following the links. For further information on any of this research or specific papers please contact us.

Alginates The Science

Dettmar, P.W., Strugala, V. and Tselepis, C. (2007). The effect of alginates on deoxycholic acid induced changes in oesophageal mucosal biology at pH 4. J. Biomater. Sci. Polymer Ed.; 18(3): 317-333. [View Abstract]

Brownlee, I.A., Allen, A., Pearson, J.P., Dettmar, P.W., Havler, M.E., Atherton, M.R. and Onsoyen, E. (2005). Alginate as a source of dietary fiber. Crit. Rev. Food Sci. Nutri.; 45(6): 497-510. [View Abstract]

Richardson, J.C., Dettmar, P.W., Hampson, F.C. and Melia, C.D. (2005). Oesophageal bioadhesion of sodium alginate suspensions 2. Suspension behaviour on oesophageal mucosa. Eur. J. Pharm. Sci.; 24(1): 107-114.
[View Abstract]

Hampson, F.C., Farndale, A., Strugala, V., Sykes, J., Jolliffe, I.G. and Dettmar, P.W. (2005). Alginate rafts and their characterisation. Int. J. Pharm.; 294(1-2): 137-147. [View Abstract]

Richardson, J.C., Dettmar, P.W., Hampson, F.C. and Melia, C.D. (2004). Oesophageal bioadhesion of sodium alginate suspensions: particle swelling and mucosal retention. Eur. J. Pharm. Sci.; 23(1): 49-56. [View Abstract]

Richardson, J.C., Dettmar, P.W., Hampson, F.C. and Melia, C.D. (2004). A simple, high throughput method for the quantification of sodium alginates on oesophageal mucosa. Eur. J. Pharm. Biopharm.; 57(2): 299-305. [View Abstract]

Richardson, J.C., Dettmar, P.W., Hampson, F.C. and Melia, C.D. (2004). The bioadhesive and swelling characteristics of sodium alginate suspensions. In: Williams, P. A. and Phillips, G. O., eds. Gums and Stabilisers for the Food Industry. 12. Cambridge, UK, The Royal Society of Chemistry: 75-83.

Strugala, V., Kennington, E.J., Skjak-Braek, G. and Dettmar, P.W. (2004). Bioactive properties of epimerised alginates. In: Williams PA, Phillips GO, eds. In: Williams, P. A. and Phillips, G. O., eds. Gums and Stabilisers for the Food Industry. 12. Cambridge, UK, The Royal Society of Chemistry: 84-94.

Boyd, M.J., Mitchell, J.R., Hampson, F.C., Jolliffe, I.G., Dettmar, P.W. and Melia, C.D. (2004). Phase separation behaviour in xanthan and sodium alginate mixtures. In: Williams, P. A. and Phillips, G. O., eds. Gums and Stabilisers for the Food Industry. 12. Cambridge, UK, The Royal Society of Chemistry: 262-271.

Alginates Clinical Studies

Dettmar, P.W., Hampson, F.C., Taubel, J., Lorch, U., Johnstone, L.M., Sykes, J. and Berry, P.J. (2007). The suppression of gastro-oesophageal reflux by alginates. Int. J. Clin. Pract.; 61(10): 1654-1662. [View Abstract]

Dettmar, P. W., Hampson, F. C., Jain, A., Choubey, S., Little, S. L., Baxter, T. (2006). Administration of an alginate based gastric relux suppressant on the bioavailability of omeprazole. Indian J. Med. Res. 123:517-524. [View Abstract]

Dettmar, P.W., Sykes, J., Little, S.L. and Bryan, J. (2006). Rapid onset of effect of sodium alginate on gastro-oesophageal reflux compared with ranitidine and omeprazole, and relationship between symptoms and reflux episodes. Int. J. Clin. Pract.; 60(3): 275-283. [View Abstract]

Dettmar, P.W., Little, S.L. and Baxter, T. (2005). The effect of omeprazole pre-treatment on rafts formed by reflux suppressant tablets containing alginate. J. Int. Med. Res.; 33(3): 301-308. [View Abstract]

Cell Biology

Gill, G.A., Johnston, N., Buda, A., Pignatelli, M., Pearson, J.P., Dettmar, P.W. and Koufman, J.A. (2005). Laryngeal epithelial defenses against laryngopharyngeal reflux: investigations of E-cadherin, carbonic anhydrase isonenzyme III, and pepsin. Ann. Otol. Rhinol Laryngol.; 114(12): 913-921.
[View Abstract]

Johnston, N., Bulmer, D., Gill, G.A., Panetti, M., Ross, P.E., Pearson, J.P., Pignatelli, M., Axford, S.E., Dettmar, P.W. and Koufman, J.A. (2003). Cell biology of laryngeal epithelial defenses in health and disease: Further studies. Ann. Otol. Rhinol. Laryngol.; 112(6): 481-491. [View Abstract]

Tucker, E., Buda, A., Janghra, N., Coad, J., Baker, J., Moorghen, M., Havler, M., Dettmar, P.W. and Pignatelli, M. (2003). Abnormalities of the cadherin-catenin complex in chemically-induced colo-rectal carcinogenesis. Proc. Nutri. Soc.; 62: 229-236. [View Abstract]

Dietary Fibre/Diet

Brownlee, I.A., Dettmar, P.W., Strugala, V. and Pearson, J.P. (2006). The Interaction of Dietary Fibres with the Colon. Curr. Nutri. Food Sci.; 2(3): 243-264.
[View Abstract]

Jennings, A., Costarelli, V., Davies, G.J. and Dettmar, P.W. (2006). Habitual dietary calcium intake and body weight in 7-10 year old children. Nutri. Food Sci.; 36(5): 337-342.

Brownlee, I.A., Atherton, M.A., Havler, M., Dettmar, P.W., Allen, A. and Pearson, J.P. (2004). The effect of dietary fibre intake on mucus secretion in the rat colon. In: Williams, P. A. and Phillips, G. O., eds. Gums and Stabilisers in the Food Industry. 12. Cambridge, UK, The Royal Society of Chemistry: 526-534.

Williams, A.W., Davies, G.J. and Dettmar, P.W. (2004). Diet and irritable bowel syndrome: study design. In: Williams, P. A. and Phillips, G. O., eds. Gums and Stabilisers for the Food Industry. 12. Cambridge, UK, The Royal Society of Chemistry: 552-559.

Jennings, A., Davies, G.J. and Dettmar, P.W. (2004). Dietary Hydrocolloids, special consideration with children. In: Williams, P. A. and Phillips, G. O., eds. Gums and Stabilisers for the Food Industry. 12. Cambridge, UK, The Royal Society of Chemistry: 581-588.

Al-Assaf, S., Phillips, G.O., Williams, P.A., Takigami, S., Dettmar, P.W. and Havler, M. (2003). Molecular weight, tertiary structure, water binding and colon behaviour of ispaghula husk fibre. Proc. Nutri. Soc.; 62: 211-216. [View Abstract]

Edwards, S., Chaplin, M.F., Blackwood, A.D. and Dettmar, P.W. (2003). Primary structure of arabinoxylans of ispaghula husk and wheat bran. Proc. Nutri. Soc.; 62(1): 217-222. [View Abstract]

Brownlee, I.A., Havler, M.E., Dettmar, P.W., Adrian, A. and Pearson, J.P. (2003). Colonic mucus: secretion and turnover in relation to dietary fibre intake. Proc. Nutri. Soc.; 62(1): 245-249. [View Abstract]

Drug Delivery

Richardson, J.C., Melia, C.D., Strugala, V. and Dettmar, P.W. (2006). An overview of polysaccharide therapeutics and future directions. In: Williams, P. A. and Phillips, G. O., eds. Gums and Stabilisers in the Food Industry. 13. Cambridge, UK, The Royal Society of Chemistry: 476-490.

Batchelor, H.K., Tang, A., Dettmar, P.W., Hampson, F.C., Jolliffe, I.G. and Craig, D.Q.M. (2004). Feasibility of a bioadhesive drug delivery system targeted to oesophageal tissue. Eur. J. Pharm. Biopharm.; 57(2): 295-298. [View Abstract]

Marshall, P., Snaar, J.E.M., Ng, Y.L., Bowtell, R.W., Hampson, F.C., Dettmar, P.W., Onsoyen, E. and Melia, C.D. (2004). Localised mapping of water movement and hydration inside a developing bioadhesive bond. J. Cont. Rel.; 95(3): 435-446. [View Abstract]

Smart, J.D., Riley, R.G., Tsibouklis, J., Young, S.A., Hampson, F.C., Davis, J.A., Kelly, G., Dettmar, P.W. and Wilber, W.R. (2003). The retention of C-14-labelled poly(acrylic acids) on gastric and oesophageal mucosa: an in vitro study. Eur. J. Pharm. Sci.; 20(1): 83-90. [View Abstract]

Gastro-oesophageal Reflux

Bor, S., Kitapcioglu, G., Dettmar, P.W. and Baxter, T. (2007). Association of heartburn during pregnancy with the risk of gastroesophageal reflux disease. Clin. Gastroenterol. Hepatol.; 5(9): 1035-1039. [View Abstract]

Imaging

Richardson, J.C., Bowtell, R.W., Mader, K. and Melia, C.D. (2005). Pharmaceutical applications of magnetic resonance imaging (MRI). Adv. Drug Del. Rev.; 57: 1191-1209. [View Abstract]

Laryngopharyngeal Reflux (LPR)

Tasker, A., Dettmar, P.W. and Pearson, J.P. (2006). Should the presence of pepsin in the middle ear be considered as a marker of prior gastric reflux? In: Giuli, R. Scarpignato, C. Collard, J-M., Richter, J.E. eds. The Duodenogastroesophageal Reflux. John Libbey pub:168-171.

Johnston, N., Dettmar, P.W., Lively, M.O., Postma, G.N., Belafsky, P.C., Birchall, M. and Koufman, J.A. (2006). Effect of pepsin on laryngeal stress protein (Sep70, Sep53 and Hsp70) response: role in laryngopharyngeal reflux disease. Ann. Otol. Rhinol Laryngol.; 115(1): 47-58. [View Abstract]

Koufman, J.A., Dettmar, P.W. and Johnston, N. (2005). Laryngopharyngeal reflux (LPR). ENT News; 14: 42-45.

Johnston, N., Knight, J., Dettmar, P.W., Lively, M.O. and Koufman, J. (2004). Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease. Laryngoscope; 114(12): 2129-2134.
[View Abstract]

Laxatives

Mitchell, J.M., Mengs, U., McPherson, S., Zijlstra, J., Dettmar, P.W., Gregson, R. and Tigner, J.C. (2006). An oral carcinogenicity and toxicology study of senna (Tinnevelly senna fruits) in the rat. Arch. Toxicol.; 80: 34-44. [View Abstract]

Marfil, C., Davies, G.J. and Dettmar, P.W. (2005). Laxative use and its relationship with straining in a london elderley population: free-living versus institutionalised. J. Nutrit. Health Ageing; 9: 185-187 [View Abstract]

Marfil, C., Davies, G.J. and Dettmar, P.W. (2005). Straining at stool and stool frequency in free-living and institutionalized older adults. J. Nutrit. Health Ageing; 9: 277-280. [View Abstract]

Mucus

Brownlee, I.A., Knight, J., Dettmar, P.W. and Pearson, J.P. (2007). Action of reactive oxygen species on colonic mucus secretions. Free Radic. Biol. Med.; 43(5): 800-808. [View Abstract]

Taylor, C., Pearson, J.P., Draget, K.I., Dettmar, P.W. and Smidsrod, O. (2005). Rheological characterisation of mixed gels of mucin and alginate. Carbohydr. Polym.; 59(2): 189-195. [View Abstract]

Taylor, C., Allen, A., Dettmar, P.W. and Pearson, J.P. (2004). Two rheologically different gastric mucus secretions with different putative functions. Biochim. Biophys. Acta-Gen. Sub.; 1674(2): 131-138. [View Abstract]

Taylor, C., Allen, A., Dettmar, P.W. and Pearson, J.P. (2003). The gel matrix of gastric mucus is maintained by a complex interplay of transient and nontransient associations. Biomacromol.; 4(4): 922-927. [View Abstract]

Strugala, V., Allen, A., Dettmar, P.W. and Pearson, J.P. (2003). Colonic mucin: methods of measuring mucus thickness. Proc. Nutri. Soc.; 62(1): 237-243.
[View Abstract]

Pepsin

Johnston, N., Dettmar, P.W., Bishwokama, B., Lively, M.O. and Koufman, J.A. (2007). Activity/stability of human pepsin: implications for reflux attributed laryngeal disease. Laryngoscope; 117:1-4. [View Abstract]

Strugala, V., Pearson, J.P., Panetti, M., Koufman, J.A. and Dettmar, P.W. (2006). Considering the still potent enzymatic activity of gastric juice at high pH values, what should be the pH threshold to consider above the UES? In: Giuli, R. Scarpignato, C. Collard, J-M., Richter, J.E. eds. The Duodenogastroesophageal Reflux. John Libbey pub:181-184.

Tasker, A., Dettmar, P.W. and Pearson, J.P. (2006). Can acid reflux be considered among the causes of middle ear effusions? In: Giuli, R. Scarpignato, C. Collard, J-M., Richter, J.E. eds. The Duodenogastroesophageal Reflux. John Libbey pub:164-168.

Knight, J., Lively, M.O., Johnston, N., Dettmar, P.W. and Koufman, J.A. (2005). Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux. Laryngoscope; 115(8): 1473-1478. [View Abstract]

Pregnancy

Derbyshire, E., Davies, G.J., Costarelli, V. and Dettmar, P.W. (2008). Habitual patterns of physical activity during pregnancy and postnatally. Br. J. Midwifery; 16(1):20-24.

Derbyshire, E.J., Davies, J. and Dettmar, P. (2007). Changes in bowel function: pregnancy and the puerperium. Dig. Dis. Sci.; 52(2):324-328. [View Abstract]

Derbyshire, E., Davies, J., Costarelli, V. and Dettmar, P.W. (2006). Prepregnancy body mass index and dietary intake in the first trimester of pregnancy. J.Hum. Nutr. Dietet.;19: 1-7. [View Abstract]

Derbyshire, E., Davies, J., Costarelli, V. and Dettmar, P.W. (2006). Diet, physical inactivity and the prevalence of constipation throughout and after pregnancy. Matern. Child Nutr.;2(3):127-134. [View Abstract]

Derbyshire, E.J., Davies, G.J. and Dettmar, P.W. (2004). Hydrocolloid intakes and bowel function during the first trimester of pregnancy. In: Williams, P. A. and Phillips, G. O., eds. Gums and Stabilisers for the Food Industry. 12. Cambridge, UK, The Royal Society of Chemistry: 589-596.

Skin Studies

Messager, S., Hann, A.C., Goddard, P.A., Dettmar, P.W. and Maillard, J.Y. (2004). Use of the 'ex vivo' test to study long-term bacterial survival on human skin and their sensitivity to antisepsis. J. App. Micro.; 97(6): 1149-1160. [View Abstract]

Messager, S., Goddard, P.A., Dettmar, P.W. and Maillard, J.Y. (2004). Comparison of two in vivo and two ex vivo tests to assess the antibacterial activity of several antiseptics. J. Hosp. Inf.; 58(2): 115-121. [View Abstract]

Marsh, L.H., Alexander, C., Coke, M., Dettmar, P.W., Havler, M., Nevell, T.G., Smart, J.D., Timmins, B. and Tsibouklis, J. (2003). Adsorbed pluronics on the skin of human volunteers: effects on bacterial adhesion. Int. J. Pharm.; 251(1-2): 155-163. [View Abstract]

Messager, S., Hann, A.C., Goddard, P.A., Dettmar, P.W. and Maillard, J.Y. (2003). Assessment of skin viability: is it necessary to use different methodologies? Skin Res. Tech.; 9(4): 321-330. [View Abstract]

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