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Bioadhesion

Bioadhesion describes the attachment of a synthetic or natural macromolecule to an epithelial/mucosal surface and has been exploited pharmaceutically to manipulate drug bioavailability. It allows the attachment of a drug carrier system to a target biological surface and enhances drug delivery as:

• Drug residence time at the site of absorption is prolonged

• The drug concentration gradient across the tissue is increased

• Tissue permeability may be modified

• Protection from metabolising enzymes can occur

Technostics have established an international reputation for the design, testing and optimisation of bioadhesive dosage forms. We have collaborated with a number of major pharmaceutical companies and co-developed novel bioadhesive systems for targeted drug delivery to the oesophageal, buccal, nasal, rectal and vaginal mucosa.